Lymphocyte dysfunction in chronic graft-versus-host disease
نویسندگان
چکیده
منابع مشابه
Lymphocyte dysfunction in chronic graft-versus-host disease.
Three recipients of HLA-identical bone marrow transplants developed chronic graft-versus-host disease (cGVHD) and hypergammaglobulinemia. All three had evidence of abnormal B-lymphocyte function, including a polyclonal increase in immunoglobulins (Ig), antinuclear antibodies, rheumatoid factor, lymphocytotoxins, and increased immune complexes. T-lymphocyte function was also abnormal, including ...
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Mr. F is a 62-year-old Caucasian man who was diagnosed with acute myelogenous leukemia (AML) 15 months prior. Following two cycles of induction chemotherapy, his AML was in remission. Four months ago, after a reduced-intensity conditioning regimen, Mr. F received an allogeneic peripheral blood stem cell transplant from his human leukocyte antigen–identical 56year-old sister. Mr. F received a re...
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Chronic graft-versus-host disease (GVHD) is an immune-mediated disorder that adversely affects quality of life and clinical outcomes in patients following hematopoietic stem cell transplantation. Conventional treatment of GVHD includes prolonged and high-dose corticosteroids; however, those drugs are associated with multiple side effects. This article describes the ability of extracorporeal pho...
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ژورنال
عنوان ژورنال: Blood
سال: 1981
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v58.4.746.746